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Researchers Examine The Psychological Impact Of Child Abuse
According to a new Mayo Clinic study, a history of child abuse significantly impacts the wide range of challenges facing depressed inpatients. Included are an increase in suicide attempts, prevalence of substance use disorder, and a higher incidence rate of personality disorder. Additionally, these victims also had an earlier onset of mental illness and an increase in psychiatric hospitalizations for psychiatric issues. The study was presented at the American Psychiatric Association 2009 Annual Meeting in San Francisco.
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Ohio Supreme Court Restricts Mifepristone Use In State To Scope Of FDA's Approval Letter
In answering two certified questions from the U.S. Court of Appeals for the 6th Circuit, the Ohio State Supreme Court on July 1 declared that a state law regulating the use of mifepristone -- which is used in medication abortion -- bars physicians from prescribing it for off-label use, BNA reports. The court confirmed that doctors who use the drug to induce abortion must do so in compliance with the 49-day gestational limit included in FDA"s 2000 drug approval letter. Doctors also must prescribe the drug in accordance with the protocols and dosage indications included in its FDA-approved labeling.Interpretation of State Law in ContentionThe Ohio General Assembly in 2004 passed a law (Section 2919.123 (A)) that required any health care professional prescribing or dispensing mifepristone to comply with "all provisions of federal law that govern the use" of the drug. The law defines "federal law" as "any law, rule or regulation of the United States or any drug approval letter" from FDA "that governs or regulates the use of" mifepristone for inducing abortion. FDA"s approval letter states that the drug "is indicated for use in the termination of pregnancy (through 49 days" pregnancy) and has no other approved indication for use during pregnancy." In addition, the drug"s label states the recommended dosage and that its use requires three office visits by the patient. Planned Parenthood Southwest Ohio Region challenged the law in district court, arguing that neither FDA"s approval letter nor any other federal provision bans the off-label use of mifespristone to induce abortion beyond 49 days" gestation. The group also argued that the state law was unconstitutionally vague because it did not notify abortion providers in advance regarding which FDA documents were included in the state"s criminal law. In addition, Planned Parenthood said that prohibiting the evidence-based use of the drug would infringe on the rights of women, requiring them to take higher-than-necessary dosages of the drug or to undergo surgical abortions when a noninvasive alternative is available. The district court ruled in favor of Planned Parenthood, saying that the law was void because of vagueness. The state appealed the decision to the 6th Circuit, which then submitted two questions to the state Supreme Court seeking its interpretation of the law.The state Supreme Court ruled that FDA"s drug approval letter is included in the definition of "federal law" and that the state law is not ambiguous, according to BNA. The court said that because the drug approval letter incorporated FDA"s labeling text, Ohio physicians cannot prescribe or provide mifepristone to induce abortion outside of the stipulations of the drug approval letter and approved label. According to BNA, product liability law experts say the ruling will not have an impact outside of mifepristone or the state of Ohio.Case Returns to Appeals CourtRoger Evans of Planned Parenthood Federation of America said that he is not sure if the court"s decision helps or hurts the group"s case. Evans said that the district court declared the law unconstitutional based on an interpretation that the statute operates in the same way the state Supreme Court ruled it does. He noted that there are other possible interpretations of the law that would have solved the constitutional issues at the center of the litigation. However, because those issues were not resolved, the case now returns to the 6th Circuit, which will decide if the statute is constitutional based on the state Supreme Court"s interpretation. If the circuit court agrees with the district court that the statute is unconstitutionally vague, the state of Ohio could seek a U.S. Supreme Court review. If the circuit court finds that the statute is constitutional, the case likely will be sent back to the district court for resolution of some other issues in the case, according to BNA (BNA, 7/6).
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3D Printing For New Tissues And Organs
A more effective way to build plastic scaffolds on which new tissues and even whole organs might be grown in the laboratory is being developed by an international collaboration between teams in Portugal and the UK.
Endocrinology

People Who Bike Or Walk To Work Are More Fit, Less Fat Than Drivers

Trying to get fit but can"t work it into your daily schedule? Incorporating even relatively short bouts of exercise into a daily commute appears to deliver significant rewards, according to a new study from the University of North Carolina at Chapel Hill. Researchers looked at the health and fitness levels of active commuters people who walk or ride a bike to work at least part of the way compared to those who drive or take public transportation. Men and women who were active commuters performed better on a fitness test, according to the study published in the July 13, 2009, issue of Archives of Internal Medicine. And men who walk or bike have lower obesity rates as well as healthier triglyceride levels, blood pressure and insulin levels, said study author Penny Gordon-Larsen, Ph.D., nutrition associate professor in UNC"s Gillings School of Global Public Health. "We don"t know why women don"t reap all the same health benefits as men," said Gordon-Larsen, an obesity epidemiologist. "We can speculate women may not be exercising as intensely or it may be that they are commuting shorter distances. But for both sexes, we see significant health benefits to walking or biking to work." For most adults, 60 minutes of brisk walking per day is sufficient to meet physical activity guidelines for avoiding weight gain, Gordon-Larsen said, and walking is an activity most people can do. "Walking or biking to work is one way to increase physical activity," said Janne Boone-Heinonen, Ph.D., a postdoctoral nutrition researcher at UNC and co-author of the study. And while the benefits of exercise in general have been studied quite a bit, she noted, not much research has been conducted on the cardiovascular and overall health benefits of "non-leisure" activities like active commuting. Gordon-Larsen and colleagues studied 2,364 adults in the Coronary Artery Risk Development in Young Adults (CARDIA) study who worked outside the home. At examinations conducted between 2005 and 2006, participants reported the length of their commute in minutes and miles, including details on the percentage of the trip taken by car, public transportation, walking or bicycling. Researchers also recorded participants" height, weight and other health variables, including blood pressure and fitness levels as assessed by a treadmill test. In addition, subjects wore an accelerometer to measure their levels of physical activity during at least four days of the study period. The average length of active commuters" trips was 20 minutes for men and 17 minutes for women. However, fewer than two in 10 (16.7 percent) of the participants used any means of active commuting to reach their workplace. The results add to existing evidence that walking or biking to work is beneficial, the authors noted. "Ultimately it would be wonderful to see more people walking and biking to work, but to make this happen, we need to make walking and biking safe and accessible by reducing environmental barriers to activity," Gordon-Larsen said. Additional research is needed to determine other potential benefits of active commuting and unravel the relationship between walking or biking to work and other health-promoting behaviors that people may engage in, the authors concluded. Along with Gordon-Larsen and Boone-Heinonen, other study authors are Steve Sidney, M.D., and Barbara Sternfeld, Ph.D., from Kaiser Permanente, Oakland, Calif.; David R. Jacobs Jr, Ph.D., from the University of Minnesota and the University of Oslo, Norway; and Cora E. Lewis, M.D., from the University of Alabama at Birmingham. University of North Carolina at Chapel Hill


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