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Prominent Bioinformatics Expert To Join Harvard School Of Public Health Faculty And Become Chair Of Dana-Farber Department Of Biostatistics
Giovanni Parmigiani, PhD, a noted leader in applying bioinformatics tools to cancer studies and medical decision-making, has been appointed professor of biostatistics at Harvard School of Public Health (HSPH) and as chair of the Department of Biostatistics and Computational Biology at Dana-Farber Cancer Institute.
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Erectile Dysfunction Might Be Associated With Chronic Periodontal Disease: Two Ends Of The Cardiovascular Spectrum
UroToday.com - Together with Drs. Heruti, Bechor, Justo and Galor, we studied 815 Israeli male adults of whom 305 had complete data and were included in the statistical analysis. In the analyzed population, 2.1% of people without erectile dysfunction (ED) had advanced periodontal disease (defined as recession of periodontal bone of 6 mm or more) in comparison to 9.8% of the mild ED and 15.8% of the moderate/severe ED populations, respectively. However, due to the relatively small groups, we could not present the odds ratio. We are now planning a large-scale study to further establish the association between the two conditions.
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ACLU Illinois Offering No-Cost Legal Advice Regarding Parental Notification Law
The American Civil Liberties Union has launched an effort to offer no-cost legal advice about an Illinois law requiring providers to notify an unmarried minor"s parents prior to performing an abortion, the AP/KWQC reports. The law, which took effect on Tuesday, was enacted in 1995. However, enforcement of the law was delayed by a series of court challenges. It requires that either a parent, grandparent, stepparent living in the home or a legal guardian be notified prior to a minor obtaining an abortion, although judges are permitted to grant exceptions. Abortion-rights opponents claim the law will ensure that parents are consulted so their children "aren"t forced into abortions," according to the AP/KWQC.In response to the law, ACLU has created a toll-free phone line and a Web site to assist girls seeking information about the judicial bypass process. Lorie Chaiten of the Illinois ACLU said the group also has been training lawyers to assist minors (AP/KWQC, 8/4).
Cardiovascular

New Statistical Method Shows Importance Of Dialysis Dose

A new approach to statistical analysis may be better suited to study the relationship between higher "dose" of dialysis and survival time for patients with advanced kidney disease, according to an upcoming paper in the Journal of the American Society of Nephrology (JASN). Some studies have shown longer survival times for patients receiving a higher dose of dialysis, while others show no such relationship. Thus, Christos Argyropoulos, MD, PhD (University of Pittsburgh Medical Center) and colleagues analyzed data from a large group of U.S. dialysis patients using the new statistical technique as well as conventional methods. The "accelerated failure time" model (inspired by considerations of what happens when kidneys cease working and many unidentified toxins start building up in the patient"s bloodstream) showed longer survival times at a higher dose of dialysis, compared to no significant effect with the conventional model. Upon analysis using this technique, patient survival increased steadily along with dialysis dose, after adjustment for other risk factors (age, heart disease, diabetes, comorbid conditions, etc). The results suggest that the conflicting results of previous studies may be related to the limitations of the statistical methods used. Small to moderately sized clinical trials may be particularly sensitive to this effect, adds Argyropoulos. "From a public health perspective, it may be reasonable to re-examine the clinical trial data with unconventional, yet scientifically valid statistical techniques and encourage relevant basic research in statistics and epidemiology to facilitate future clinical studies in this area." The study was limited by the lack of follow-up information on the dose of dialysis the patients received at multiple clinic visits. "Consequently, no conclusions could or should be drawn about the validity of existing national and international guidelines concerning an adequate dialysis dose," says Argyropoulos. He also stresses that the findings cannot be generalized to non-U.S. patients. Co-authors included Chung-Chou H. Chang, PhD, and Mark Unruh, MD (University of Pittsburgh); Nancy Fink, MPH (John Hopkins University, Baltimore); and Laura Plantinga, MSc, and Neil Powe, MD (University of California, San Francisco). The research was supported by an unrestricted grant through the Renal Discoveries Baxter Extramural Grant program from Baxter Healthcare International to the authors and by grants from the Agency of Healthcare Research and Quality (AHRQ), the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Heart, Lung and Blood Institute (NHLBI). American Society of Nephrology


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