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Thermo Scientific DNA Polymerases And Master Mixes Improve Yield And Specificity In PCR Amplifications
Thermo Fisher Scientific Inc., the world leader in serving science, announced it offers a premium collection of Thermo Scientific Taq DNA polymerases that are licensed and optimised for use in PCR processes. ThermoPrime Taq DNA Polymerase and Thermo-Start® Taq DNA Polymerase are designed to provide excellent amplification specificity and improved product yield. In addition, the high purity of these enzymes ensures their consistent and reliable performance.
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Vehicle Designed For Blind To Take The Wheel
A student team in the Virginia Tech College of Engineering is providing the blind with an opportunity many never thought possible: The opportunity to drive.
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Asymptomatic Perioperative Myocardial Injury Affects Vascular Outcomes
A new study reports that 75 percent of cardiac damage after vascular surgery is asymptomatic or patients" symptoms are concealed by postoperative complaints such as nausea and incision pain. This damage is associated with an increased risk for mortality. Researchers have found that screening for cardiac damage following surgery helps identify high-risk patients who might benefit from more aggressive medical therapy and follow-up after discharge. These findings are from a study presented today at the 63rd Annual Meeting of the Society for Vascular Surgery®.
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New Piece Found In Colorectal Cancer Puzzle

Prostasin, a relatively unknown protease enzyme expressed in most epithelial cells, may play a role in the genesis of colorectal cancer. Researchers writing in the open access journal BMC Cancer have associated a reduction in the expression of inhibitors of the enzyme with malignant cellular behavior. Lotte Vogel, from the University of Copenhagen, worked with a team of Danish and Norwegian researchers to investigate levels of prostasin and its inhibitors in colorectal tissue samples from 222 patients and 23 controls. They found that the mRNA levels of the inhibitor of prostasin, PN-1, increased at both the transition between normal tissue and mild/moderate dysplasia and again at the transition between severe dysplasia and colorectal cancer. According to Vogel, "It has previously been shown that overexpression of prostasin in mammary and prostate cancer cells reduces the invasive properties of cancer cells and that high prostasin expression in gastric tumours is associated with longer survival. In what may be support for this trend, our data shows that elevated mRNA levels for prostasin"s inhibitor, PN-1, coincides with the acquisition of malignant properties in colorectal tissue". The enzymatic activity of prostasin is almost certainly influenced by levels of inhibitors other than PN1, and PN1 itself is known to inhibit many other enzymes. This complex web of interactions between relevant proteases and their inhibitors makes firm conclusions difficult to draw. As Vogel writes, "Future studies are required to clarify whether down-regulation of prostasin activity via up regulation of PN-1 is causing the malignant progression or if it is a consequence of it". Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis Joanna Selzer-Plon, Jette Bornholdt, Stine Friis, Hanne C Bisgaard, Inger M. B. Lothe, Kjell M. Tveit, Elin H Kure, Ulla Vogel and Lotte K. Vogel BMC Cancer (in press) Article. All articles are available free of charge, according to BioMed Central"s open access policy. Graeme Baldwin BioMed Central


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