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Raltegravir Combination Treatment For HIV Is A Safe And Effective Alternative To Efavirenz In Treatment-Naive Patients
Use of the HIV antiretroviral treatment raltegravir, in combination with optimum background therapy, is a safe and effective alternative to conventional combination treatment using efavirenz in patients yet to start antiretroviral treatment. Furthermore, the raltegravir regimen is faster acting and causes fewer adverse events than the efavirenz regimen. These are the conclusions of an Article published Online First and in an upcoming edition of The Lancet, written by Dr Jeffrey L Lennox, Emory University School of Medicine, Atlanta, GA, USA, and colleagues.
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Link Between Depression, Suicidal Thoughts and Later Parental-Mandated Bedtimes For Teens

Earlier parental-mandated bedtimes could help protect teens from depression and suicidal thoughts by lengthening sleep duration, according to a research abstract presented at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies. The study by James Gangwisch, PhD, of Columbia University in New York, examined data from 15,659 adolescents. A total of 1,143 teens (7.3 percent) suffered from depression and 2,038 (13 percent) had suicidal thoughts. Adolescents with parental-mandated bedtimes at midnight or later were 25 percent more likely to suffer from depression and 20 percent more likely to have suicidal ideation compared with adolescents who had parental-mandated bedtimes of 10 p.m. or earlier. "It is a common perception and societal expectation that adolescents do not need as much sleep as preadolescents, yet studies suggests that adolescents may actually require more sleep," said Gangwisch. "Studies have found that adolescents do not go to bed early enough to compensate for earlier school start times, and transitions to earlier school start times have been shown to be associated with significant sleep deprivation." According to Gangwisch, the study supports the argument that inadequate sleep could lead to depression. "Adolescents with later parental-mandated bedtimes went to bed later, got less sleep, and were less likely to get enough sleep. Short sleep duration explained the relationship between parental-mandated bedtimes and depression, functioning as a risk factor for depression and suicidal ideation." Abstract Title: Earlier Parental Mandated Bedtimes for Adolescents as a Protective Factor against Depression and Suicidal Ideation as Mediated by Sleep Duration Presentation Date: Tuesday, June 9 Category: Sleep in Psychiatric Disorders Abstract ID: 1064 Kelly Wagner American Academy of Sleep Medicine


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