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New Study Results Published Compare ABRAXANE(R) To Taxotere(R)
Abraxis BioScience Inc. (NASDAQ:ABII) announced that final results from an open-label Phase II study evaluating three dose levels of the company"s chemotherapy agent ABRAXANE® for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin bound) compared to the highest standard dose of Taxotere (docetaxel) Injection Concentrate, in the first-line treatment of patients with metastatic breast cancer were published in the Journal of Clinical Oncology. According to investigator-assessed results, ABRAXANE administered weekly at 150 mg/m2 demonstrated an increase in progression-free survival (PFS) over docetaxel of 14.6 months versus 7.8 months, respectively (p=0.012). Results from the independent assessment of PFS for the 150mg/m2 treatment arm also demonstrated an increase in PFS (12.9 versus 7.5 months, respectively; p=0.0065). Investigators also noted a trend toward improvement in the study"s primary endpoint, overall response rate (ORR), confirmed complete and partial responses by Response Evaluation Criteria in Solid Tumors (RECIST) criteria with weekly ABRAXANE. In investigator-assessed results, the ORR was 74 percent for ABRAXANE 150 mg/m2 weekly arm (pAbout the Study
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Swine Flu Update, UK
On Wednesday 3 June 2009 the situation in the UK was as follows:
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New Analysis Shows Efficacy Of SIMPONI(TM) (golimumab) In Anti-TNF Experienced Rheumatoid Arthritis Patients
A new analysis demonstrated that a greater proportion of patients with moderately to severely active rheumatoid arthritis (RA) who had prior treatment with anti-tumor necrosis factor (TNF)-alpha agents and received subcutaneous injections of SIMPONI(TM) (golimumab) once every four weeks experienced significant improvements in signs and symptoms through week 24, compared with patients receiving placebo. Patients continued to receive stable doses of methotrexate, sulfasalazine and/or hydroxychloroquine if receiving them at baseline. These data were presented at the 2009 European League Against Rheumatism (EULAR) Annual Congress.
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Legislation To Overhaul U.S. Foreign Aid Introduced

Senator John Kerry (D-Mass.), chairman of the Senate Foreign Relations Committee, and ranking member, Senator Richard Lugar (R-Ind.), on Tuesday "introduced a bill to overhaul the U.S. system for providing global development aid," the Boston Globe reports (Smith, 7/29). The legislation was also introduced by Senators Robert Menendez (D-NJ) and Bob Corker (R-Tenn.), according to a release from Menendez"s office (7/28). The bill proposes "numerous changes in the way aid is allocated" and would strengthen USAID, "which has withered in recent years as aid programs were shifted to other departments, including the Pentagon," according to the Boston Globe. "The bill would require increased coordination and transparency in U.S. aid programs, reestablish a bureau for strategic planning within USAID, and give more authority to USAID staffers in the field," writes the newspaper (7/29). According to the press release, the Foreign Assistance Revitalization and Accountability Act of 2009, S.1524, would also establish "an independent council in the executive branch - the Council on Research and Evaluation of Foreign Assistance (CORE) - to objectively evaluate the impact and results of all development and foreign aid programs undertaken by the U.S. Government" (7/28). The Boston Globe reports that "[m]any development groups have pushed the Obama administration to address the fragmented foreign-aid process." Raymond Offenheiser, Oxfam America"s president, said that "[a]long with rebuilding USAID, the U.S. must shift its focus from development projects that meet short-term political and security goals back to long-term development goals that not only help more people escape poverty, but in the long run, create greater stability and good will for the U.S." (7/29). In the press release, Kerry said, "We need cutting edge programs that will push the envelope on ending chronic poverty, combating global climate change, reducing hunger, supporting democracies, and offering alternatives to extremism." Lugar said that although the U.S. "has increased development funding and elevated its priority," USAID has been "allowed to atrophy. Many new programs are located outside USAID in roughly two dozen departments and agencies. We don"t really know whether these programs are complementary or working at cross-purposes." Menendez said that foreign assistance has been "pulled in too many directions" over the years and that the "reform initiative is a way to help focus our programs in a smarter and more effective way." Corker said, "This bill begins to reinvigorate USAID to improve the coordination, execution and efficiency of U.S. assistance so we can make each dollar go farther" (7/28). This information was reprinted from globalhealth.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Global Health Policy Report, search the archives and sign up for email delivery at globalhealth.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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