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Increase In Contraception Sales, Vasectomies Linked To Recession, Slate Column Says
The "hard truth of our economic turmoil is almost at term," as hospitals are beginning to report a decrease in the number of births, about nine months after "American banks first admitted their collective crisis," author Lauren Sandler writes in Slate"s "The Big Money" column. Sandler writes that the trend is "hardly unprecedented," noting that the contraception business "was just about the only one booming" during the Great Depression. She asks, "Are market forces the great contraceptive?" Sandler continues that in the first few months of 2009, Nielsen reported a 10% increase in U.S. sales of condoms and emergency contraceptive pills. Additionally, sales of the permanent female contraceptive Essure have increased 28% over the past year, and clicks on physician profiles on Vasectomy.com have risen 40%. According to Sandler, Vasectomy.com"s chief operating officer, Maya Wank, reports that many urologists say that vasectomies are increasing because patients" salaries are down, with many men seeking vasectomies out of fear of job or health insurance loss.Sandler writes that the "tanking economy has delivered an awakening" that the "choice to have a child is probably the most serious, not to mention one of the most costly, that you"ll ever make." According to Sandler, a Gallup poll found that 12% of women say they know someone who has delayed a planned pregnancy because of the recession. The poll also found that one in five women reports that she is more concerned about unintended pregnancy than she was one year ago, and the same number reports being more "conscientious" about using birth control. Additionally, the poll found that, compared with one year ago, 13% more women who use hormonal contraception are concerned that they will be unable to afford their birth control. Since 2008, there has been an increase of 15% in the number of U.S. residents who say they had to cut back on medications due to cost.Sandler writes that it is "not surprising" that the National Network of Abortion Funds reports a fourfold increase in the number of calls from women who need assistance paying for abortion procedures. The Centers for Disease Control and Prevention also recently announced that teen birth rates are up after a 14-year decline. "In other words, the recession could result in a drop in birth rates for women with easy access to contraception and abortion," Sandler writes, adding that experts believe that women with "more limited access ... may see the rate climb." Sandler concludes that "it"s not unreasonable to consider what things will look like if the middle class reduces its reproduction, while men and women who are struggling to even afford condoms expand their numbers despite their personal choice" (Sandler, "The Big Money," Slate, 5/17).
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Breastfeeding Can Save 1.3M Children Annually, WHO Says To Mark World Breastfeeding Week
About 1.3 million children"s lives could be saved each year by teaching new mothers how to breastfeed, but many women do not receive help and stop trying, the WHO said on Friday ahead of the start of World Breastfeeding Week, which runs from August 1 through August 7, Reuters reports. "Less than 40 percent of mothers worldwide breastfeed their infants exclusively in the first six months, as recommended by the WHO," the news service writes. Constanza Vallenas, a WHO medical officer in the Department of Child and Adolescent Health and Development, said women "don"t have the practical support" to help them get their infants to latch on properly and find a technique that prevents pain and discomfort. Vallenas said the problem exists in both rich and poor countries, and she called for "more assistance in hospitals, health clinics and communities for new mothers who need information and help," according to Reuters (MacInnis, 7/31).
News of the day
Former Ghanaian President Named World Food Programme Ambassador
John Kofi Agyekum Kufuor, a former president of Ghana, has been named a global ambassador against hunger for the U.N."s World Food Programme (WFP), Xinhua reports. According to the news service, Kufuor will "help to underline the importance of fighting hunger on several fronts - by investing in long-term agricultural development, but also by funding WFP"s work in tackling urgent hunger needs and helping the hungry poor to access affordable and nutritious food" (Ooko, 7/20).
Mental Health

Behavioral Effects Of Addiction Enhanced By Cocaine-Linked Genes

New research sheds light on how cocaine regulates gene expression in a crucial reward region of the brain to elicit long-lasting changes in behavior. The study, published by Cell Press in the May 14th issue of the journal Neuron, provides exciting insight into the molecular pathways regulated by cocaine and may lead to new strategies for battling drug addiction. It is well established that addictive drugs induce persistent changes in the brain"s reward circuits. Previous research has indicated that addiction to drugs such as cocaine is associated with altered gene expression in the nucleus accumbens (NAc), a region of the brain that is involved in motivation, pleasure, and reward. "Although we have known for some time that changes in gene expression contribute to the long-lasting regulation of the brain"s reward circuitry that is seen during drug addiction, how those specific genes are regulated is not well understood," explains senior study author, Dr. Eric J. Nestler from the Department of Neuroscience at the Mount Sinai School of Medicine. Dr. Nestler and colleagues combined sophisticated and highly sensitive genetic isolation and screening techniques to study regulation of gene transcription in the mouse NAc, including regulation of chromatin structure, after repeated administration of cocaine. The results of this novel analysis significantly refined the understanding of cocaine-regulated gene transcription in general, and advanced knowledge of the specific role of two transcription factors known to play a prominent role in cocaine-induced addiction. The researchers also identified a previously unrecognized family of genes, called the sirtuins, as being involved in cocaine addiction in the NAc. Chronic cocaine administration was linked with an increase in sirtuin gene transcription while increased sirtuin activity in NAc neurons was associated with a potentiation of the rewarding effects of cocaine. Importantly, pharmacological inhibition of sirtuins in the NAc reduced the rewarding effects of cocaine and the motivation to self-administer the drug. Taken together, the results identify a subset of genes that are highly likely to be targets of cocaine and shed light on the specific mechanisms that underlie cocaine-induced changes in the NAc. "Our findings underscore the vast clinical potential of the many new gene targets identified in this study for the development of more effective treatments of cocaine and potentially other drug addictions," concludes Dr. Nestler. The researchers include William Renthal, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Arvind Kumar, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Guanghua Xiao, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Matthew Wilkinson, Mount Sinai School of Medicine, New York, NY; Herbert E. Covington III, Mount Sinai School of Medicine, New York, NY; Ian Maze, Mount Sinai School of Medicine, New York, NY; Devanjan Sikder, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Alfred J. Robison, Mount Sinai School of Medicine, New York, NY; Quincey LaPlant, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, Mount Sinai School of Medicine, New York, NY; David M. Dietz, Mount Sinai School of Medicine, New York, NY; Scott J. Russo, Mount Sinai School of Medicine, New York, NY; Vincent Vialou, Mount Sinai School of Medicine, New York, NY; Sumana Chakravarty, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Thomas J. Kodadek, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Ashley Stack, Florida State University, Tallahassee, FL; Mohamed Kabbaj, Florida State University, Tallahassee, FL; and Eric J. Nestler, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, Mount Sinai School of Medicine, New York, NY. Cathleen Genova Cell Press


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