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Boston University Biomedical Engineer Wins Hartwell Foundation Grant To Create Pediatric Blood Vessel Grafts That Grow With The Child
Boston University Biomedical Engineer Joyce Wong will work to create engineered blood vessels aimed at correcting pediatric heart defects under a major grant from The Hartwell Foundation. Wong is one of just 12 researchers nationwide to win the foundation"s prestigious Individual Biomedical Research Award.
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Biological 'Fountain Of Youth' Discovered In New World Bat Caves
Scientists from Texas are batty over a new discovery which could lead to the single most important medical breakthrough in human history - significantly longer lifespans. The discovery, featured on the cover of the July 2009 print issue of The FASEB Journal, shows that proper protein folding over time in long-lived bats explains why they live significantly longer than other mammals of comparable size, such as mice.
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Likelihood Of Placental-Site Trophoblastic Tumors Linked To The Amount Of Time Since Related Pregnancy
An article published Online First and in a future edition of The Lancet discusses the management of a rare condition called placental-site trophoblastic tumors (PSTTs). They are malignant tumors usually presenting months to years after pregnancy. The chances of surviving those tumors are linked to how much time elapsed since the related pregnancy took place. The article is written by Dr Peter Schmid and Professor Michael J Seckl, of the Imperial College NHS Healthcare Trust, London, UK, and colleagues. This paper is a milestone and the first study in thirty years to inform on a complete national experience of the disease. It represents the world"s largest series.
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A Link Between The Circadian Rhythm And Salt Balance

New research, conducted by Charles Wingo and his colleagues, at the University of Florida, Gainsville, suggests a link between the circadian rhythm and control of sodium (salt) levels in mice. The hormone aldosterone regulates levels of sodium in the blood and thereby helps control blood pressure. Although it is known that aldosterone regulates sodium levels by controlling expression of the alpha-subunit of the epithelial sodium channel (alpha-ENaC) in the kidney, the molecular pathway by which aldosterone modulates alpha-ENaC levels has not been determined. In a previous study to address this issue, Wingo and colleagues found that aldosterone induced expression of the circadian clock gene Per1 in mouse cells, but the effects of this induction were not investigated. In this new study, they have revealed that the protein produced from the Per1 gene (Period 1) regulates expression of alpha-ENaC in the mouse kidney. Importantly, in the absence of Period 1, expression of alpha-ENaC in the mouse kidney was decreased and sodium loss in the urine was increased. Since expression from the Per1 gene seemed to follow a circadian pattern, the authors suggest that the circadian clock has a role in balancing sodium levels in the body. TITLE: The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice Karen Honey Journal of Clinical Investigation


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